九州大学薬学研究院薬理学分野

・ライフイノベーション分野へ(to Dept. Life innovation)


2015


Kohro Y, Sakaguchi E, Tashima R, Tozaki-Saitoh H, Okano H, Inoue K, Tsuda M
A new minimally-invasive method for microinjection into the mouse spinal dorsal horn.
Sci Rep, 2015

Tsuda M, Inoue K
Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration.
Neuropharmacology, 2015

Masuda T, Iwamoto S, Mikuriya S, Tozaki-Saitoh H, Tamura T, Tsuda M, Inoue K
Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia.
J Pharmacol Sci, 2015

Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.
Nat Med, 2015

2014


Akagi T, Matsumura Y, Yasui M, Minami E, Inoue H, Masuda T, Tozaki-Saitoh H, Tamura T, Mizumura K, Tsuda M, Kiyama H, Inoue K.
Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents.
J Pharmacol Sci. 2014

Ochi-Ishi R, Nagata K, Inoue T, Tozaki-Saitoh H, Tsuda M, Inoue K.
Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia.
Mol Pain. 2014

Yasui M, Yoshimura T, Takeuchi S, Tokizane K, Tsuda M, Inoue K, Kiyama H.
A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation.
Glia. 2014

Tsuda M, Matsushita K, Inoue K.
[Neuropathic pain].
Nihon Yakurigaku Zasshi. 2014

Masuda T, Iwamoto S, Yoshinaga R, Tozaki-Saitoh H, Nishiyama A, Mak TW, Tamura T, Tsuda M, Inoue K.
Transcription factor IRF5 drives P2X4R+ reactive microglia gating neuropathic pain.
Nat. Commun., 2014


Yasui M, Takashi Y, Takeuchi S, Tokizane K, Tsuda M, Inoue K, Kiyama H.
Continuous stress elicits mechanical allodynia and muscular hyperalgesia via spinal microglial activation.
Glia, 2014

Masuda T, Nishimoto N, Tomiyama D, Matsuda T, Tozaki-Saitoh H, Tamura T, Kohsaka S, Tsuda M, Inoue K.
IRF8 is a transcriptional determinant for microglial motility
Purinergic Signalling, 2014

Matsushita K, Tozaki-Saitoh H, Kojima C, Masuda T, Tsuda M, Inoue K, Hoka S.
Chemokine (C-C motif) Receptor 5 Is an Important Pathological Regulator in the Development and Maintenance of Neuropathic Pain.
Anesthesiology, 2014

2013


Tsuda M, Masuda T, Tozaki-Saitoh H, Inoue K.
P2X4 receptors and neuropathic pain.
Front Cell Neurosci., 2013

Inoue K.
[The neuropharmacological study of ATP receptors especially in pain].
Yakugaku Zasshi., 2013

Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H.
The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S.
Sci Rep., 2013

Masuda T, Tsuda M, Tozaki-Saitoh H, Inoue K.
Intrathecal infusion of microglia cells.
Methods Mol Biol., 2013

Masuda T, Tsuda M, Tozaki-Saitoh H, Inoue K.
Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor.
Methods Mol Biol., 2013

Tsuda M, Masuda T, Tozaki-Saitoh H, Inoue K.
Microglial regulation of neuropathic pain.
J Pharmacol Sci., 2013

Igawa T, Higashi S, Abe Y, Ohkuri T, TanakaH, Morimoto S, Yamashita T, Tsuda M, Inoue K, Ueda T.
Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor.
J Biochem. 2013

Nakaya M, Tajima M, Kosako H, Hashimoto A, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Inoue K, Kurose H.
GKR6-deficient mice exhibit reduced recycling of senescent red blood cells and impaired apoptotic cell clearance causing autoimmunity.
Nature Communications. 2013

2012


Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi H.
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
J Neurosci. 2012

Koizumi S, Ohsawa K, Inoue K, Kohsaka S.
Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors.
Glia. 2012

Kumamaru H, Saiwai H, Kobayakawa K, Kubota K, Rooijen NV, Inoue K, Iwamoto Y, Okada S.
Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures.
J Neuroinflammation. 2012

Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inoue
IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype.
Cell Reports, 2012

Uesugi A, Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Robaye B, Boeynaems JM, Inoue K.
Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis.
Glia. 2012

Ohsawa K, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.
J Neurochem. 2012

Toyomitsu E, Tsuda M, Yamashita T, Tozaki-Saitoh H, Tanaka Y, Inoue K.
CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia.
Purinergic Signal. 2012

Tsuda M, Tozaki-Saitoh H, Inoue K.
Purinergic system, microglia and neuropathic pain.
Curr Opin Pharmacol. 2012

Inoue K, Tsuda M.
Purinergic systems, neuropathic pain and the role of microglia.
Exp Neurol. 2012

2011


Nishida M, Ogushi M, Suda R, Toyotaka M, Saiki S, Kitajima N, Nakaya M, Kim KM, Ide T, Sato Y, Inoue K, Kurose H.
Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB.
Proc Natl Acad Sci U S A. 2011

Hayashi Y, Kawaji K, Sun L, Zhang X, Koyano K, Yokoyama T, Kohsaka S, Inoue K, Nakanishi H.
Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain.
J Neurosci. 2011

Inoue K, Tsuda M.
Purinergic systems, neuropathic pain and the role of microglia.
Exp Neurol. 2011

Toulme E, Tsuda M, Khakh BS, Inoue K.
On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory and Neuropathic Pain.
In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton, FL: CRC Press; 2010. Chapter 10.

Tsuda M, Tozaki-Saitoh H, Inoue K.
Platelet-activating factor and pain.
Biol Pharm Bull. 2011

Kuboyama K, Tsuda M, Tsutsui M, Toyohara Y, Tozaki-Saitoh H, Shimokawa H, Yanagihara N, Inoue K.
Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases.
Mol Pain, 2011

Tozaki-Saitoh H, Tsuda M, Inoue K.
Role of purinergic receptors in CNS function and neuroprotection.
Adv Pharmacol., 2011

Kataoka A, Koga Y, Uesugi A, Tozaki-Saitoh H, Tsuda M, Inoue K.
Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways. Purinergic Signaling, 2011

Kuboyama K, Harada H, Tozaki-Saitoh H, Tsuda M, Ushijima K, Inoue K.
Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
J Cereb Blood Flow Metab., 2011

Biber K, Tsuda M, Tozaki-Saitoh H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K.
Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development.
EMBO J, 4;30(9):1864-73, 2011

M. Tsuda, Y. Kohro, T. Yano, T. Tsujikawa, J. Kitano, H. Tozaki-Saitoh, S. Koyanagi, S. Ohdo, R-R Ji, M. W. Salter, K. Inoue.
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.
Brain, 134:1127-39, 2011


2010


E. Toulme, M. Tsuda, B. S. Khakh and K. Inoue.
Role of P2X receptors in pain.
Translational Pain Research: From Mouse to Man, CRC Press


H.Tozaki-Saitoh, M. Tsuda, and K. Inoue
Role of purinergic receptors in neuroprotection.
Purine and Pyrimidine Receptor: Advances in Pharmacology, in press

K. Inoue, F. Kato, M. Tsuda.
The modulation of synaptic transmission by the glial purinergic system.
The Open Neuroscience Journal Special Issue on "Purinergic Signalling in Epilepsy”

Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S.
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
Mol Pain., 26;6:83, 2010

Tozaki-Saitoh H, Tsuda M, Inoue K.
Purinergic regulation of microglia
Nippon Yakurigaku Zasshi, 136(2):93-7, 2010

Maeda M, Tsuda M, Tozaki-Saitoh H, Inoue K, Kiyama H.
Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn.
Glia., 58(15):1838-46, 2010

Tsuda M, Tozaki-Saitoh H, Inoue K.
Pain and purinergic signaling.
Brain Res Rev., 63(1-2):222-32, 2010

Ohsawa K, Irino Y, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.
P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP.
Glia., 58(7):790-801, 2010

M. Shiratori*, H. Tozaki-Saitoh*, M. Yoshitake, M. Tsuda, K. Inoue.
P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways.
J Neurochem., 114(3):810-9, 2010
*These authors contributed equally to this work

Hasegawa S, Kohro Y, Shiratori M, Ishii S, Shimizu T, Tsuda M, Inoue K.
Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain.
PLoS One, 5(5):e10467, 2010.


2009


Tsuda M, Kuboyama K, Inoue T, Nagata K, Tozaki-Saitoh H, Inoue K.
Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays.
Mol. Pain, 11;5(1):28, 2009

Masuda J*, Tsuda M*, Tozaki-Saitoh H, Kazuhide Inoue
Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia
Mol. Pain, 5:23, 2009
*These authors contributed equally to this work

Shinozaki Y, Sumitomo K, Tsuda M, Koizumi S, Inoue K, Torimitsu K.
Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors.
PLoS Biol., 5;7(5):e103, 2009

Nagata K*, Imai K*, Yamashita T, Tozaki-Saitoh H, Tsuda M, Inoue K
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief. *These authors contributed equally to this work
Mol. Pain, 23;5:20, 2009

Hasegawa S, Kohro Y, Tsuda M, Inoue K
Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.
Mol. Pain, 2;5(1):22, 2009

Tsuda M*, Masuda T*, Kitano J, Shimoyama H, Tozaki-Saitoh H, Inoue K.
IFN-{gamma} receptor signaling mediates spinal microglia activation driving neuropathic pain.
*These authors contributed equally to this work
Proc Natl Acad Sci U S A. 2009

Inoue K, Tsuda M.
Microglia and neuropathic pain.
Glia. 2009

Tsuda M*, Toyomitsu E*, Kometani M, Tozaki-Saitoh H, Inoue K.
Mechanisms underlying fibronectin-induced upregulation of P2XR expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signaling pathways.
*These authors contributed equally to this work
J Cell Mol Med. 2009

Fujita T, Tozaki-Saitoh H, Inoue K.
P2Y(1) receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures.
Glia. 2009, 57(3):244-57

Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K.
Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT.
J Neurochem. 2009, 108(1):115-25


2008


Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira K, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Ohno Y, Inoue K, Sawada J
The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.
Biochem Pharmacol. 2008 Oct 15;76(8):1006-13

Miyazaki N, Nakatsuka T, Takeda D, Nohda K, Inoue K, Yoshida M.
Adenosine modulates excitatory synaptic transmission and suppresses neuronal death induced by ischaemia in rat spinal motoneurones.
Pflugers Arch. 2008 Nov;457(2):441-51

Suzuki T, Tamehiro N, Sato Y, Kobayashi T, Ishii-Watabe A, Shinozaki Y, Nishimaki-Mogami T, Hashimoto T, Asakawa Y, Inoue K, Ohno Y, Yamaguchi T, Kawanishi T.
The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression.
J Pharmacol Sci. 2008 Jul;107(3):285-94

Nishida M, Sato Y, Uemura A, Narita Y, Tozaki-Saitoh H, Nakaya M, Ide T, Suzuki K, Inoue K, Nagao T, Kurose H.
P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis.
EMBO J. 2008, 27(23):3104-15

Tang Y, Matsuoka I, Ono T, Inoue K, Kimura J.
Selective up-regulation of P2X4-receptor gene expression by interferon-gamma in vascular endothelial cells.
J Pharmacol Sci., 107(4):419-27, 2008

Inoue K.
Purinergic systems in microglia.
Cell Mol Life Sci., 65(19):3074-80, 2008

Yamada J, Hayashi Y, Jinno S, Wu Z, Inoue K, Kohsaka S, Nakanishi H.
Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy.
Glia., 56(13):1448-62, 2008

Nakatsuka T, Fujita T, Inoue K, Kumamoto E.
Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin.
J Physiol., 586(10):2511-22, 2008

Tozaki-Saitoh H, Tsuda M, Miyata H, Ueda K, Kohsaka S, Inoue K.
P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury.
J Neurosci. 7;28(19):4949-56, 2008

Irino Y, Nakamura Y, Inoue K, Kohsaka S, Ohsawa K.
Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.
J Neurosci. Res. 15;86(7):1511-9, 2008

Tsuda M, Toyomitsu E, Komatsu T, Masuda T, Kunifusa E, Nasu-Tada K, Koizumi S, Yamamoto K, Ando J, Inoue K
Fibronectin/integrin system is involved in P2X4 receptor upregulation in the spinal cord and neuropathic pain after nerve injury.
Glia 56(5):579-85, 2008

Tsuda M*, Ueno H*, Kataoka A, Tozaki-Saitoh H, Inoue K.
Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. *These authors contributed equally to this work
Glia 56(4):378-86, 2008

Tsuda M, Tozaki-Saitoh H, Masuda T, Toyomitsu E, Tezuka T, Yamamoto T and Inoue K
Lyn tyrosine kinase is required for P2X4 receptor upregulation and neuropathic pain after peripheral nerve injury.
Glia 56(1):50-8, 2008


2007


Inoue K, Tsuda M, Tozaki-Saitoh H.
Modification of neuropathic pain sensation through microglial ATP receptors.
Purinergic Signaling 3(4):311-6, 2007

Inoue K.
P2 receptors and chronic pain.
Purinergic Signaling 3(1-2):135-44, 2007

Biber K, Neumann H, Inoue K, Boddeke HW.
Neuronal 'On' and 'Off' signals control microglia.
Trends Neurosci 30(11):596-602, 2007

Kono Y, Shigetomi E, Inoue K, Kato F
Facilitation of spontaneous glycine release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat.
Eur J Neurosci 25(6):1748-1756, 2007

Kazuhide Inoue, Schuichi Koizumi, Makoto Tsuda
The role of nucleotides in the neuron-glia communication responsible for the brain functions.
J Neurochem 102(5):1447-58, 2007

Makoto Tsuda*, Shigeo Hasegawa*, Kazuhide Inoue (*: These authors are equally contributed)
P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain.
J Neurochem 103(4):1408-16, 2007

Makoto Tsuda, Satoshi Ishii, Takahiro Masuda, Shigeo Hasegawa, Koji Nakamura, Kenichiro Nagata, Tomohiro Yamashita, Hidemasa Furue, Hidetoshi Tozaki-Saito, Megumu Yoshimura, Schuichi Koizumi, Takao Shimizu & Kazuhide Inoue.
Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.
J Neurochem 102(5):1658-1668, 2007

Y. Shinozaki, Y. Sato, S. Koizumi, Y. Ohno, T. Nagao and K. Inoue.
Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of JNK and p38 mitogen-activated protein kinase.
Neuroscience 147:153-63, 2007

H. Ikeda, M. Tsuda, K. Inoue, K. Murase.
Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn.
Eur J Neurosci. 25:1297-1306, 2007

S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B.V. Joshi, K.A. Jacobson, S. Kohsaka, K. Inoue.
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.
Nature, 446, 1091-1095, 2007

Ohsawa K, Irino Y, Nakamura Y, Akazawa C, Inoue K, Kohsaka S.
Involvement of P2X(4) and P2Y(12) receptors in ATP-induced microglial chemotaxis.
Glia. 55:604-616, 2007

Ikeda R, Takahashi Y, Inoue K, Kato F.
NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain.
Pain 127:161-172, 2007


2006


Shinozaki Y, Koizumi S, Ohno Y, Nagao T, Inoue K.
Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes.
Glia. 2006 Nov 1;54(6):606-618.

Inoue K.
ATP receptors of microglia involved in pain.
Novartis Found Symp.2006;276:263-72; discussion 273-81. Review.

Suzuki T, Hide I, Matsubara A, Hama C, Harada K, Miyano K, Andra M, Matsubayashi H, Sakai N, Kohsaka S, Inoue K, Nakata Y.
Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role.
J Neurosci Res. 2006 Jun;83(8):1461-70

Shiokawa H, Nakatsuka T, Furue H, Tsuda M, Katafuchi T, Inoue K, Yoshimura M.
Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors.
J Physiol. 2006 Jun 15;573(Pt 3):753-63, 2006

Hiranita T, Nawata Y, Sakimura K, Anggadiredja K, Yamamoto T.:
Suppression of methamphetamine-seeking behavior by nicotinic agonists.
Proc Natl Acad Sci USA. 2006 May 30;103(22):8523-8527.

Suzuki T, Nishimaki-Mogami T, Kawai H, Kobayashi T, Shinozaki Y, Sato Y, Hashimoto T, Asakawa Y, Inoue K, Ohno Y, Hayakawa T, Kawanishi T.
Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives.
Phytomedicine. 2006 Jun;13(6):401-11. Epub 2005 Oct 28.

Tozaki-Saitoh H, Koizumi S, Sato Y, Tsuda M, Nagao T, Inoue K.
Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC12 cells.
Mol Pharmacol. 2006 Apr 25; [Epub ahead of print]

Nasu-Tada K*, Koizumi S*, Tsuda M*, Kunifusa E, Inoue K.
Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X(4), a key molecule for mechanical allodynia.
Glia. 2006 May;53(7):769-775. *: These authors are equally contributed

Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M.:
5Alpha-bile alcohols function as farnesoid X receptor antagonists.
Biochem Biophys Res Commun 339: 386-391 (2006).


Inoue K:
The function of microglia through purinergic receptors: Neuropathic pain and cytokine release.
Pharmacol Ther 109: 210-226 (2006)



2005


Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438:1017-1021 (2005).

Sato Y, Nakamura R, Satoh M, Fujishita K, Mori S, Ishida S, Yamaguchi T, Inoue K, Nagao T, Ohno Y:
Thyroid hormone targets matrix gla protein gene associated with vascular smooth muscle calcification.
Circ Res 97:550-557 (2005).


Narita M, Miyatake M, Shibasaki M, Tsuda M, Koizumi S, Narita M, Yajima Y, Inoue K, Suzuki T:
Long-lasting change in brain dynamics induced by methamphetamine: enhancement of protein kinase C-dependent astrocytic response and behavioral sensitization.
J Neurochem. 2005 Jun;93(6):1383-92.


Nasu-Tada K, Koizumi S, Inoue K:
Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin: Different regulations by ADP through PKA.
Glia. 2005 Nov 1;52(2):98-107.


Tamehiro N, Sato Y, Suzuki T, Hashimoto T, Asakawa Y, Yokoyama S, Kawanishi T, Ohno Y, Inoue K, Nagao T, Nishimaki-Mogami T.:
Riccardin C: a natural product that functions as a liver X receptor (LXR)alpha agonist and an LXRbeta antagonist.
FEBS Lett 579(24):5299-5304 (2005).


Kanayasu-Toyoda T, Fujino T, Oshizawa T, Suzuki T, Nishimaki-Mogami T, Sato Y, Sawada J, Inoue K, Shudo K, Ohno Y, Yamaguchi T.:
HX531, a retinoid X receptor antagonist, inhibited the 9-cis retinoic acid-induced binding with steroid receptor coactivator-1 as detected by surface plasmon resonance.
J Steroid Biochem Mol Biol 94(4):303-309 (2005).


Tsuda M, Inoue K, Salter MW:
Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia.
Trends Neurosci 28,101-107 (2005)
.

Inoue K, Denda M, Tozaki H, Fujishita K, Koizumi S, Inoue K:
Characterization of multiple P2X receptors in cultured normal human epidermal keratinocytes.
J Invest Dermatol 124, 756-763 (2005)
.


2004


Kawamura M, Gachet C, Inoue K, Kato F:
Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice.
J Neurosci. 2004 Dec 1;24(48):10835-45.

Koizumi S, Fujishita K, Inoue K, Shigemoto-Mogami Y, Tsuda M, Inoue K:
Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation.
Biochem J. 380, 329-338 (2004).

Shinozaki Y, Koizumi S, Ishida S, Sawada J, Ohno Y, Inoue K:
Cytoprotection against oxidative-stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors.
Glia 49, 288-300 (2004)
.

Anggadiredja K, Nakamichi M, Hiranita T, Tanaka H, Shoyama Y, Watanabe S, Yamamoto T:
Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade,
Neuropsychopharmacology 29, 1470-1478 (2004)
.

Matsumoto Y, Yamaguchi T, Watanabe S, Yamamoto Y:
Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1beta,
Neuropharmacology 46, 1195-1200 (2004).


Nishimaki-Mogami T, Une M, Fujino T, Sato Y, Tamehiro N, Kawahara Y, Shudo K, Inoue K.
Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor.
J Lipid Res. 45: 1538-1545 (2004).


Suzuki S, Nishimaki-Mogami T, Tamehiro N, Inoue K, Arakawa R, Abe-Dohmae S, Tanaka RT, Ueda K, Yokoyama S:
Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via an LXR-independent mechanism.
Arterioscler Thromb Vasc Biol 24:519-525 (2004)

Inoue K, Tsuda M, Koizumi S: ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. J Pharmacol Sci 94, 112-114 (2004).

Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K:
Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury.
Glia 45, 89-95 (2004).

Inoue K, Tsuda M, Koizumi S:
Chronic pain and microglia: the role of ATP.
Novartis Found Symp261, 55-64 (2004)


Yamamoto T, Anggadiredja K, Hiranita T:
New perspectives in the studies on endocannabinoid and cannabis: a role for the endocannabinoid-arachidonic acid pathway in drug reward and long-lasting relapse to drug taking.
J Pharmacol Sci 96, 382-328 (2004)

Hiranita T, Anggadiredja K, Fujisaki C, Watanabe S, Yamamoto T:
Nicotine attenuates relapse to methamphetamine-seeking behavior (craving) in rats.
Ann N Y Acad Sci 1025, 504-507 (2004)
.

Yamaguchi T, Kubota T, Kanematsu T, Nakayama K, Hirata M, Yamamoto T:
Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1.
Brain Res1025, 237-240 (2004).


Anggadiredja K, Sakimura K, Hiranita T, Yamamoto T:
Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward.
Brain Res 1021, 272-276 (2004).

Kagamiishi Y, Yamamoto T, Watanabe S:
Detrimental role of corticotropin-releasing factor on the decrease of CA1 field potential induced by in vitro ischemia in rat hippocampal slices.
J Pharmacol
Sci 94, 39-44 (2004).

Yamaguchi T, Kubota T, Watanabe S, Yamamoto T:
Activation of brain prostanoid EP3 receptors via arachidonic acid cascade during behavioral suppression induced by Delta8-tetrahydrocannabinol.
J Neurochem 88, 148-154 (2004)
.

Fujino T, Une M, Imanaka T, Inoue K, Nishimaki-Mogami T.
Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.
J Lipid Res 42: 132-138 (2004)



2003


Fujino T, Sato Y, Une M, Kanayasu-Toyoda T, Yamaguchi T, Shudo K, Inoue K, Nishimaki-Mogami T.
In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association.
J Steroid Biochem Mol Biol 87: 247-252 (2003).


Inoue K, Koizumi S, Tsuda M, Shigemoto-Mogami Y:
Signaling of ATP receptors in glia-neuron interaction and pain.
Life Sci 74, 189-197 (2003).

Kagamiishi Y, Yamamoto T, Watanabe S:
Hippocampal serotonergic system is involved in anxiety-like behavior induced by corticotropin-releasing factor.
Brain Res 991, 212-221 (2003)
.

Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K:
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.
Nature 424, 778-783 (2003).

Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Kita A, Inoue K:
A dynamic regulation by astrocytic ATP of excitatory synaptic transmission in cultured rat hippocampal neurons.
Pro.Natl.Acad.Sci.USA, 100, 11023-11028 (2003)
.

Anggadiredja K, Yamaguchi T, Tanaka H, Shoyama Y, Watanabe S, Yamamoto T:
Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice.
Brain Res 966, 47-53 (2003).

Publications

  主要論文
1. M. Tsuda et al.,
       Nature, 2003

2. J.A.M. Coull et al.,
       Nature, 2005

3. S. Koizumi et al.,
       Nature, 2007

4. M. Nakaya et al.,
      Nat Commun., 2013

5. T. Masuda et al.,
      Nat Commun., 2014

6. M. Shiratori-Hayashi et al.,
      Nat Med., 2015

7. Y. Hayashi et al.,
      Nat Commun., 2016

8. T. Masuda et al.,
      Nat Commun., 2016

9. S. Koyanagi et al.,
      Nat Commun., 2016

年度別
Dept.LifeInnovation
2013
2012
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003



九州大学